Scientific Principles

Blending millennia of Traditional Chinese Medicine wisdom with modern supramolecular technology to deliver a scientifically effective scalp care solution.

The principles of Jun-Chen-Zuo-Shi formula composition

A modern, scientifically formulated system rooted in 1,000 years of Traditional Chinese Medicine wisdom.

Jun

Chief ingredient

Ellagic Acid: Targets Mitochondrial Repair in Hair Follicles

Scientific Basis: Research published in the 2024 edition of *Journal of Ethnopharmacology*, along with multiple studies, confirms that ellagic acid protects and repairs mitochondrial function in hair follicles damaged by DHT, restores ATP production, and reverses follicular miniaturization.

Mechanism of Action: Activates the Wnt signaling pathway, inhibits ferroptosis, and promotes the transition of hair follicles from the telogen to the anagen phase.

Technical Breakthrough: Ellagic acid has extremely low natural water solubility. Our team used supramolecular self-assembly technology to formulate ellagic acid into nanoparticles, increasing its equilibrium solubility by 120 times and significantly enhancing transdermal absorption.

Clinical Validation: Tested on over 300 participants, after continuous use for 12 weeks, 92% showed significant improvement in scalp condition and a 35% increase in hair strength.

Subject

Assistant herb

Core Ingredients: Sanguisorba + Sophora – Optimizing the Scalp Microenvironment

Sanguisorba: Cools blood, stops bleeding, clears heat and toxins; tightens scalp pores to reduce oil production.

Sophora: Clears heat and dries dampness; inhibits bacteria and relieves itching. Suppresses the growth of pathogens like Malassezia to soothe scalp itchiness and inflammation.

Synergistic Effect: The ministering herb acts as a "cleaner" that deep-cleans the soil by removing excess oil, bacteria, and inflammation blocking hair follicle growth, restoring clarity to the environment. Only in a clean environment can the chief herb (ellagic acid) reach deep into the follicles to perform its core function of repairing mitochondria and supplying energy. Together, they deliver amplified results.

supporting and guiding

assistant

Sichuan Peppercorn Oil: Enhancing Penetration and Targeted Delivery

Function: Promotes local circulation and dilates capillaries. Its key active ingredients, limonene and linalool, temporarily open skin barrier channels to help active compounds penetrate the stratum corneum and reach deep into hair follicles.

Innovation

Foam formulation

Feature: Innovative foam formulation

Horizontal Spread: Foams penetrate through hair to cover a larger scalp area. Refreshing & No-Rinse: Vaporizes instantly upon contact with the scalp, leaving no greasy residue—no rinsing required. Easy to Use: One-press application improves user compliance.

Schematic diagram of supramolecular technologyTechnical Comparison Chart

Supramolecular Technology

Supramolecules are molecular aggregates formed through the ordered assembly of non-covalent interactions. Ellagic acid's extremely low water solubility (below 10 μg/ml) has been a major barrier to its application. To address this, a research team from Nanjing University of Chinese Medicine developed an ellagic acid supramolecule based on intermolecular hydrogen bonding (PubMed PMID: 38278106). This structure increases equilibrium solubility by 120-fold and significantly enhances in vitro transdermal delivery, enabling non-invasive deep-skin drug transport and substantially boosting its efficacy in promoting hair regrowth. Core technologies have been granted Chinese invention patents.

Technical Advantages:

  • 120x higher solubility, breaking absorption limits
  • Significantly enhanced transdermal performance; in vitro studies confirm non-invasive delivery to deep skin layers (fascia).
  • Excellent stability, uniform nanoparticles, and low tendency to agglomerate.
  • Supramolecular technology significantly enhances the bioavailability of ellagic acid without altering its molecular structure, ensuring active ingredients are effectively absorbed and utilized. This provides a solid scientific foundation for scalp care.

Ellagic Acid: Ingredient Analysis

Scientific Basis and Mechanism of Action for Key Ingredients

What is ellagic acid?

Ellagic Acid, a polyphenol primarily extracted from natural sources like pomegranates and raspberries, plays a key role in the "Nanyan Xinsi" Scalp Serum by repairing mitochondrial function in hair follicles (the energy hubs), protecting against DHT damage, and nurturing the scalp environment at its source to promote stronger, healthier hair.

Antioxidant effect

Effectively neutralizes free radicals to reduce oxidative stress damage to scalp cells and delay scalp aging.

Soothing Repair

Relieves scalp discomfort, strengthens the scalp barrier, and promotes a healthy scalp environment.

Gentle & Safe

Naturally plant-derived, gentle and non-irritating, suitable for long-term use.

synergy

Synergizes with other plant ingredients to enhance overall care results

Technical Comparison Advantages

FeaturesNanyan New SilkTraditional Products
Formulation PhilosophyScientific formulation based on the "Ruler, Minister, Assistant, and Guide" principlesSingle-ingredient stacking
Technical ProcessesSupramolecular TechnologyConventional Hybrid Process
Ingredient UptakeNano-level penetrationSurface Effect
Lasting effectssustained-release long-actingFleeting
Backed by R&DUniversity Research TeamsCommercial Formula

Explore the Mysteries of Science

Discover our research capabilities and expert team, and experience the transformative power of technology for scalp health.